Recombinant Human CCL27/CTACK Protein (Sumo Tag)

• Background:

  CCL27/CTACK, also known as CTACK, is a small cytokine belonging to the CC chemokine family. Members of this family are proteins characterized by two adjacent cysteines. CCL27/CTACK is chemotactic for skin-associated memory T lymphocytes. CCL27/CTACK may also play a role in mediating homing of lymphocytes to cutaneous sites. CCL27/CTACK plays a pivotal role in establishing the inflammatory infiltrate characteristic for common inflammatory skin diseases. Throμgh binding to the chemokine receptor 1 (CCR1), CCL27/CTACK mediates inflammation by promoting lymphocyte migration into the skin.

• Abbreviation:

  CCL27/CTACK

• Synonyms:

  CCL; SCYA; CCL27; ALP; CTACK; CTAK; ESKINE; ILC; PESKY; SCYA27; CC Chemokine ILC; C-C Motif Chemokine 27; Cutaneous T-Cell-Attracting Chemokine; IL-11 R-Alpha-Locus Chemokine; Skinkine; Small-Inducible Cytokine A27; Chemokine (C-C motif) ligand 27; Cutaneous T cell attracting chemokine; IL 11 R alpha locus chemokine; member 27; Small inducible cytokine A27; small inducible cytokine subfamily A (Cys-Cys)

• UniProt:

  Q9Y4X3

• Accession Number:

  Q9Y4X3

• Expression System:

  E. coli

• Tag:

  N-Sumo

• Sequence:

  Phe25-Gly112

• Field of Research:

  Immunology

• Endotoxin:

  < 10 EU/mg of the protein as determined by the LAL method.

• Purity:

  > 90% as determined by reducing SDS-PAGE.

• Bioactivity:

  Not validated for activity

• Reconstitution:

  It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

• Shipping Conditions:

  This product is provided as lyophilized powder which is shipped with ice packs.

• Storage Conditions:

  Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

• Calculated Molecular Weight:

  22.6 kDa

• Observed Molecular Weight:

  28 kDa

• Formulation:

  Lyophilized from a 0.2 µm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

• Species:

  Human