Myogenin (Skeletal Muscle Marker)

• Gene Name:

  [MYOG]

• NCBI Gene ID:

  4656

• Reactivity:

  Human. Others not known.

• Specificity:

  Myogenin is a member of the MyoD family of myogenic basic helix-loop-helix (bHLH) transcription factors that also includes MyoD, Myf-5, and MRF4 (also known as herculinor Myf-6). MyoD family members are expressed exclusively in skeletal muscle and play a key role in activating myogenesis by binding to enhancer sequences of muscle-specific genes. The regulatory domain of MyoD is approximately 70 amino acids in length and includes both a basic DNA binding motif and a bHLH dimerization motif. MyoD family members share about 80% amino acid homology in their bHLH motifs. Anti-myogenin labels the nuclei of myoblasts in developing muscle tissue, and is expressed in tumor cell nuclei of rhabdomyosarcoma and some leiomyosarcomas. Positive nuclear staining may occur in Wilms tumor.

• Other Gene Names:

  [MYOG; MYOG; MYF4; myf-4; bHLHc3; BHLHC3; MYF4; bHLHc3; Myf-4]

• Short Name:

  [Myogenin]

• Other Product Names:

  [myogenin; Myogenin; myogenin; myogenin; Class C basic helix-loop-helix protein 3; bHLHc3; Myogenic factor 4; Myf-4]

• NCBI GI Number:

  18765727

• NCBI Accession Number:

  NP_002470.2

• NCBI GB Accession Number:

  NM_002479.5

• Uniprot Accession Number:

  P15173