Sitagliptin (phosphate monohydrate) (Standard)

• CAS Number:

  654671-77-9

• UNSPSC Description:

  Sitagliptin (phosphate monohydrate) (Standard) is the analytical standard of Sitagliptin (phosphate monohydrate). This product is intended for research and analytical applications. Sitagliptin phosphate monohydrate (MK-0431 phosphate monohydrate) is a potent inhibitor of DPP4 with an IC50 of 19 nM in Caco-2 cell extracts[1].

• Target Antigen:

  Autophagy; Dipeptidyl Peptidase

• Type:

  Reference Standards

• Related Pathways:

  Autophagy;Metabolic Enzyme/Protease

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/sitagliptin-phosphate-monohydrate-standard.html

• Smiles:

  [H]O[H].O=C(N1CC2=NN=C(C(F)(F)F)N2CC1)C[C@H](N)CC3=CC(F)=C(F)C=C3F.O=P(O)(O)O

• Molecular Weight:

  523.32

• References & Citations:

  [1]Thomas, L., et al. (R)-8-(3-amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylm ethyl)-3,7-dihydro-purine-2,6-dione (BI 1356), a novel xanthine-based dipeptidyl peptidase 4 inhibitor, has a superior potency and longer duration of acti|[2]Kim, S.J., et al., Dipeptidyl peptidase IV inhibition with MK0431 improves islet graft survival in diabetic NOD mice partially via T-cell modulation. Diabetes, 2009. 58(3): p. 641-51.|[3]Sangle, G.V., et al., Novel biological action of the dipeptidylpeptidase-IV inhibitor, sitagliptin, as a GLP-1 secretagogue. Endocrinology, 2012. 153(2): p. 564-73.|[4]Kim, S.J., et al., Inhibition of dipeptidyl peptidase IV with sitagliptin (MK0431) prolongs islet graft survival in streptozotocin-induced diabetic mice. Diabetes, 2008. 57(5): p. 1331-9.|[5]Beconi, M.G., et al. Disposition of the dipeptidyl peptidase 4 inhibitor sitagliptin in rats and dogs. Drug Metab Dispos, 2007. 35(4): p. 525-32.

• Shipping Conditions:

  Room temperature