Amyloid precursor C-terminal peptide

• CAS Number:

  201293-38-1

• UNSPSC Description:

  Amyloid precursor C-terminal peptide is cleaved from the C-terminus of Amyloid Precursor Protein (APP). Amyloid precursor C-terminal peptide accumulation causes mitochondrial morphology alteration and basal mitophagy failure, which indicates that amyloid precursor protein C-terminal peptide may correspond to an etiological trigger of Alzheimer’s disease (AD) pathology[1].

• Target Antigen:

  Mitochondrial Metabolism

• Type:

  Peptides

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/amyloid-precursor-c-terminal-peptide.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(N)=O)C(N2[C@@H](CCC2)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC3=CC=C(C=C3)O)C(N[C@@H](CCCCN)C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CC5=CC=CC=C5)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCSC)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(N)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN

• Molecular Weight:

  1896.04

• References & Citations:

  [1]Vaillant-Beuchot L, et al., Accumulation of amyloid precursor protein C-terminal fragments triggers mitochondrial structure, function, and mitophagy defects in Alzheimer's disease models and human brains. Acta Neuropathol. 2021 Jan;141(1):39-65.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported