Lamin A, Cleavage Site (Small Subunit)

• NCBI Gene ID:

  4000

• Reactivity:

  Human, Mouse, Rat

• Storage Conditions:

  May be stored at 4 °C for short-term only. For long-term storage, store at -20 °C. Aliquots are stable for at least 12 months at -20 °C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

• Specificity:

  Detects endogenous levels of the small fragment of lamin A when cleaved by caspase-6 at Asp230. It is a marker of caspase-6 activity. Detects the small fragment of lamin A/C only when cleaved at Asp230. Does not crossreact with full length lamin A (nor with lamin C). Species Crossreactivity: Mouse and rat.

• Other Gene Names:

  [LMNA; LMNA; FPL; IDC; LFP; CDDC; EMD2; FPLD; HGPS; LDP1; LMN1; LMNC; PRO1; CDCD1; CMD1A; FPLD2; LMNL1; CMT2B1; LGMD1B; LMN1]

• Short Name:

  [Lamin A, Cleavage Site]

• Other Product Names:

  [lamin isoform A; Prelamin-A/C; lamin; 70 kDa lamin; prelamin-A/C; lamin A/C-like 1; renal carcinoma antigen NY-REN-32; lamin A/C; 70 kDa lamin; Renal carcinoma antigen NY-REN-32]

• NCBI GI Number:

  27436946

• NCBI Accession Number:

  NP_733821.1

• NCBI GB Accession Number:

  NM_170707.3

• Uniprot Accession Number:

  P02545