Recombinant Mouse Cyclophilin A Protein

• Background:

  Peptidyl-prolyl cis-trans isomerase A is a cytoplasm protein which belongs to the cyclophilin-type PPIase family and PPIase A subfamily. Cyclophilins (CyPs) are a family of proteins found in organisms ranging from prokaryotes to humans. These molecules exhibit peptidyl-prolyl isomerase activity, suggesting that they influence the conformation of proteins in cells. Cyclophilin A accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Cyclophilin A can interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions.

• Abbreviation:

  Cyclophilin A

• Synonyms:

  CYPA ; Cyclophilin A; Cyclosporin A-binding protein; PPIA; PPIase A; Peptidyl-prolyl cis-trans isomerase A; Rotamase A; SP18

• Accession Number:

  P17742

• Expression System:

  E. coli

• Tag:

  None

• Sequence:

  Met1-Leu164

• Endotoxin:

  < 1.0 EU per μg of the protein as determined by the LAL method.

• Purity:

  > 95 % as determined by reducing SDS-PAGE.

• Bioactivity:

  Not validated for activity

• Reconstitution:

  Not Applicable

• Shipping Conditions:

  This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

• Storage Conditions:

  Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

• Calculated Molecular Weight:

  18.0 kDa

• Observed Molecular Weight:

  16 kDa

• Formulation:

  Supplied as a 0.2 µm filtered solution of PBS, 10% Glycerol, pH 7.4.

• Species:

  Mouse