Gabapentin

• CAS Number:

  60142-96-3

• UNSPSC Description:

  Gabapentin is a potent, orally active P/Q type Ca2+ channel blocker. Gabapentin inhibits neuronal Ca2+ influx and reduction of neurotransmitter release. Gabapentin is a GABA analog that can be used to relieve neuropathic pain[1][2][3].

• Target Antigen:

  Calcium Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel;Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Gabapentin.html

• Purity:

  98.0

• Solubility:

  DMSO : 1 mg/mL (ultrasonic)|H2O : 50 mg/mL (ultrasonic)

• Smiles:

  O=C(O)CC1(CN)CCCCC1

• Molecular Weight:

  171.24

• References & Citations:

  [1]Fink K, et, al. Inhibition of neuronal Ca(2+) influx by gabapentin and subsequent reduction of neurotransmitter release from rat neocortical slices. Br J Pharmacol. 2000 Jun;130(4):900-6.|[2]Celikyurt IK, et, al. Gabapentin, A GABA analogue, enhances cognitive performance in mice. Neurosci Lett. 2011 Apr 1;492(2):124-8.|[3]Meymandi MS, et, al. Gabapentin action and interaction on the antinociceptive effect of morphine on visceral pain in mice. Eur J Anaesthesiol. 2008 Feb;25(2):129-34.ACS Pharmacol Transl Sci. 2023 Mar 6.|Cell Rep. 2019 Dec 17;29(12):3847-3858.e5.|iScience. 2023 Jun 27.|J Nat Med. 2021 Sep 12.|J Pain. 2019 May;20(5):577-591. |Pharmacol Res Perspect. 2021 Oct;9(5):e00879.|Sci Total Environ. 2022 Jul 10;829:154437.|Eur J Drug Metab Pharmacokinet. 2022 Jun 22.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  Store at room temperature 3 years

• Clinical Information:

  Launched