Tazemetostat de(methyl morpholine)-COOH

• CAS Number:

  2685873-44-1

• UNSPSC Description:

  Tazemetostat de(methyl morpholine)-COOH (compound 7) is a ligand for the PROTAC target protein EZH2, which can be used to synthesis of EZH2 degraders (PROTACs). EZH2 degraders have potent cell viability inhibition in diffuse large B-cell lymphoma (DLBCL) and other subtypes of lymphoma[1].

• Target Antigen:

  Ligands for Target Protein for PROTAC

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/tazemetostat-de-methyl-morpholine-cooh.html

• Solubility:

  DMSO : 220 mg/mL (ultrasonic)

• Smiles:

  O=C(C1=CC=C(C2=CC(C(NCC3=C(C)C=C(C)NC3=O)=O)=C(C)C(N(C4CCOCC4)CC)=C2)C=C1)O

• Molecular Weight:

  517.62

• References & Citations:

  [1]Tu Y, Sun Y, et al. Design, Synthesis, and Evaluation of VHL-Based EZH2 Degraders to Enhance Therapeutic Activity against Lymphoma. J Med Chem. 2021 Jul 22;64(14):10167-10184.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported