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|
Cytokeratin 20 Clone: Ks20.8 The SIGNET Cytokeratin 20 (Clone Ks20.8)
reacts with the 46 kDa cytokeratin intermediate filament protein as
identified on immunoblots. Clone Ks20.8 reacts with intestinal and
gastric foveolar epithelium, endocrine cells of the upper portions of
the pyloric glands, as well as with the urethelium and Merkel’s cells in
epidermis. Most other epithelial cells, including epithelial cells of
the breast are not stained with the antibody. It does not recognize
other intermediate filament proteins. There seems to be a marked
difference in the expression of cytokeratin 20 between different types
of carcinomas. The neoplasms with positive cytokeratin 20 staining are
derived from normal epithelia expressing cytokeratin 20. Colorectal
carcinomas consistently express cytokeratin 20 while adenocarcinomas of
the stomach express cytokeratin 20 to a lesser degree. Other
adenocarcinomas including the gall bladder, bile ducts, ductal cell
adenocarcinomas of the pancreas, mucinous ovarian tumors have been found
to stain positively with the Cytokeratin 20 antibody. On the other hand,
other carcinomas such as adenocarcinomas of the breast, lung and
endometrium and non-mucinous tumors of the ovary have been found to be
negative with the cytokeratin 20 antibody. |
|||
| Catalog # | Format | Quantity | Price |
| 720-26 | Level 2 predilute | 6ml | 154.80 |