Catestatin

A New Hypertension / Stress / Insomnia / Cancer Biomarker

acts as a potent endogenous nicotinic cholinergic antagonist to inhibit catecholamine release.
induces release of histamine from mast cells.
displays potent antimicrobial activity

Relationship of CHGA-mediated dense-core secretory granule (DCG) biogenesis, catecholamine (CA) secretion, and its subsequent inhibition by the CHGA-derived peptide catestatin in the maintenance of blood pressure by the adrenal gland. CHGA, as a full-length molecule, initiates dense-core secretory granule biogenesis at the trans-Golgi network of adrenal chromaffin cells. Current data suggests that CHGA enhances granule biogenesis by preventing posttranslational degradation of other granule proteins in the Golgi complex. In the cytoplasm, catecholamine is synthesized and transported into the dense-core secretory granules via vesicular monoamine transporters. Upon stimulation by acetylcholine (Ach), catecholamine is coreleased with CHGA and catestatin from the granules. Secreted catecholamine triggers cardiovascular target cells to augment blood flow. This sympathoadrenal activity is then antagonized by the action of catestatin on cholinergic receptors to inhibit catecholamine secretion. [Ca2+]i, intracellular calcium concentration.

Taeyoon Kim and Y. Peng Loh. J. Clin. Invest. 115:1711-1713 (2005)

Cat #	Product	Quantity	Price
FC3-G-053-27	Catestatin (Human) - Cy3 Labeled Purified IgG	100 µl	709 €
FC3-053-27	Catestatin (Human) - Cy3 Labeled	1 nmol	394 €
RK-053-27	Catestatin (Human) RIA Kit	1 kit	616 €
G-053-27	Catestatin (Human) - Purified IgG Antibody	100 µg	394 €
FC5-G-053-27	Catestatin (Human) - Cy5 Labeled Purified IgG	100 µl	709 €
T-053-27	Catestatin (Human) - I-125 Labeled	10 µCi	765 €
EK-053-27	Catestatin (Human)	1 kit	462 €
H-053-27	Catestatin (Human) - Antibody for Western Blot	100 µl	394 €
FG-G-053-27A	Catestatin (Human) - FAM Labeled Purified IgG	100 µl	524 €
B-053-27	Catestatin (Human) - Biotin Labeled	10 µg	277 €
FEK-053-27	Catestatin (Human)	1 kit	585 €
FG-053-27B	Catestatin (Human) - FITC Labeled	1 nmol	277 €
FG-G-053-27B	Catestatin (Human) - FITC Labeled Purified IgG	100 µl	524 €
B-G-053-27	Catestatin (Human) - Biotin Labeled Purified IgG	100 µl	524 €
FC5-053-27	Catestatin (Human) - Cy5 Labeled	1 nmol	394 €
FG-053-27A	Catestatin (Human) - FAM Labeled	1 nmol	277 €
FR-G-053-27	Catestatin (Human) - Rhodamine Labeled Purified IgG	100 µl	641 €
053-27	Catestatin (Human)	200 µg	154 €
FG-053-28B	Catestatin (Mouse) - FITC Labeled	1 nmol	277 €
FC3-053-28	Catestatin (Mouse) - Cy3 Labeled	1 nmol	394 €
G-053-28	Catestatin (Mouse) - Purified IgG Antibody	100 µg	394 €
FG-G-053-28A	Catestatin (Mouse) - FAM Labeled Purified IgG	100 µl	462 €
H-053-28	Catestatin (Mouse) - Antiserum for Immunohistochemistry	100 ul	394 €
T-053-28	Catestatin (Mouse) - I-125 Labeled	10 µCi	765 €
FG-G-053-28B	Catestatin (Mouse) - FITC Labeled Purified IgG	100 µl	462 €
B-G-053-28	Catestatin (Mouse) - Biotin labeled purified IgG	100 µl	462 €
B-053-28	Catestatin (Mouse) - Biotin Labeled	10 µg	277 €
053-28	Catestatin (Mouse)	200 µg	154 €
FR-G-053-28	Catestatin (Mouse) - Rhodamine Labeled Purified IgG	100 µl	518 €
FC3-G-053-28	Catestatin (Mouse) - Cy3 Labeled Purified IgG	100 µl	585 €
FG-053-28A	Catestatin (Mouse) - FAM Labeled	1 nmol	277 €
FC5-053-28	Catestatin (Mouse) - Cy5 Labeled	1 nmol	394 €
RK-053-28	Catestatin (Mouse) RIA Kit	1 kit	616 €
FC5-G-053-28	Catestatin (Mouse) - Cy5 Labeled Purified IgG	100 µl	585 €
FG-053-29B	Catestatin (Rat) - FITC Labeled	1 nmol	277 €
FC3-053-29	Catestatin (Rat) - Cy3 Labeled	1 nmol	394 €
EK-053-29	Catestatin (Rat)	1 kit	462 €
FG-G-053-29A	Catestatin (Rat) - FAM Labeled Purified IgG	100 µl	462 €
H-053-29	Catestatin (Rat) - Antiserum for Immunohistochemistry	100 µl	394 €
T-053-29	Catestatin (Rat) - I-125 Labeled	10 µCi	765 €
FEK-053-29	Catestatin (Rat)	96 well - Fluorescent EIA Kit	585 €
FG-G-053-29B	Catestatin (Rat) - FAM Labeled Purified IgG	100 µl	462 €
B-G-053-29	Catestatin (Rat) - Biotin labeled purified IgG	100 µl	462 €
B-053-29	Catestatin (Rat) - Biotin Labeled	10 µg	277 €
053-29	Catestatin (Rat)	200 µg	154 €
FR-G-053-29	Catestatin (Rat) - Rhodamine Labeled Purified IgG	100 µl	518 €
FC3-G-053-29	Catestatin (Rat) - Cy3 Labeled Purified IgG	100 µl	585 €
FG-053-29A	Catestatin (Rat) - FAM Labeled	1 nmol	277 €
FC5-053-29	Catestatin (Rat) - Cy5 Labeled	1 nmol	394 €
G-053-29	Catestatin (Rat) - Purified IgG Antibody	100 µg	369 €
FC5-G-053-29	Catestatin (Rat) - Cy5 Labeled Purified IgG	100 µl	585 €

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Send mail to webmaster@gentaur.com with questions or comments about this web site.
Copyright © 2008 Gentaur Molecular Products
Site powered by Acid Dragon (AC)
Last modified: 07/15/09