Catalog Number: 24345 Price: 299 Euro/ 100ug
Lot Number: R5601
Quantity: 100 mg in 100 ml (1 mg/ml) in PBS containing 0.02% sodium azide.
Description: The p53 tumor suppressor protein induces cell cycle arrest or apoptosis in response to cellular stresses. PRG3 (p53-responsive gene 3), is induced specifically under p53-dependent apoptotic conditions in human colon cancer cells. PRG3 has significant homology to bacterial oxidoreductases and the apoptosis-inducing factor, AIF. Unlike AIF, PRG3 localizes in the cytoplasm and its ectopic expression induces apoptosis. The PRG3 gene is thus a novel p53 target gene in a p53-dependent apoptosis pathway.
Host Species: Rabbit
Specificity: Reacts with residues 170-185 [VTLIHSQVALADKELL] of the 41 kDa human PRG3 protein. This sequence is 87% identical in mouse.
Applications: Western blot – Use at 1:500 dilution. However, the investigator should determine the optimal dilution for a specific application such as immunohistochemistry.
Format: Affinity purified IgG
Storage: Maintain at +2-8°C for 3 months or at -20°C for longer periods. Stable for 1 year. Avoid repeated freeze-thaw cycles.
Reference: Ohiro Y. et al. FEBS Lett. 2002 Jul 31;524(1-3):163-71.
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